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  • Aging
  • Aging disrupts the balance in complex biological processes and reduces skin firmness and suppleness.
  • The most visible sign of aging is the change in the appearance of the skin. With aging, the outer skin layer thins and becomes itchy and dry, while connective tissue loses strength and elasticity. Blood vessels become more fragile, as do nerve endings, and the protective subcutaneous fat layer is lost. Emotional and environmental stress (heat, pollution, UV radiations, sun exposure) are major challenges, as neurons have low regenerative potential and limited antioxidant defenses. Therefore, an endogenous peptide not derived from plants or animals such as DNP™, is helpful in combating the visible signs of extrinsic aging.
  • Skin like a baby’s
  • DNP™ enhances anti-aging benefits that may be used for skin protection, wrinkle reduction, skin hydration, improvement in skin feel and appearance.
  • DNP™ enhances anti-aging benefits that may be used for skin protection, wrinkle reduction, skin hydration, and skin whitening. There is significant clinical evidence to support the topical efficacy of Nevaline™.

    Amazing healing without scars. This thorough and immediate skin repair activity is due to an endogenous peptide which is expressed at high levels during pregnancy and early childhood.

  • “Often, fetal surgeries heal without any trace of scarring. The fetus recovers from severe surgical trauma with its pristine, unblemished skin intact.”
  • Boris M. Petrikovsky, M.D., PhD, Senior Scientific Advisor
  • Neuroprotection
  • DNP™ helps prevent neural degeneration of the human skin.
  • The truck driver on the right received much more sunlight on the left side of his face than on the right. The UV radiation from that excessive sun exposure caused premature facial aging. The dramatic differences in a single face demonstrate the degree of photodamage that typically occurs gradually as we age.
  • *Unilateral Dermatoheliosis, Jennifer R.S. Gordon, M.D., and Joaquin C. Brieva, M.D. N Engl J Med 2012; 366:e25April 19, 2012
  • “Aging is associated with a loss of neurons. Neuronal degeneration affects both the central nervous system, being responsible for cognitive ability decline, and the peripheral nervous system. In the skin, "neurodegeneration" causes sensory perception decrease and multiple physiological impairments such as altered thermoregulation, limited sweating, hypopigmentation, and impaired wound healing. The majority of cutaneous nervous endings are located in superficial layers of the skin. Environmental stress (heat, pollution, UV radiations) is a major challenge, as neurons have a low regenerative potential, and limited antioxidant defenses. Therefore, neuroprotection is needed to oppose "extrinsic aging" of the skin's nervous network.”
  • Jean-Francois Nicolay, Research Director, Exsymol-Monaco
  • Free Radicals
  • DNP™ helps reduce free radicals and enhances anti-inflammation and anti-oxidation effects.
  • Unchecked free radicals cause damage, inflammation and aging.
  • “All skin cells begin to produce excess amounts of free radicals. These are unstable oxygen molecules that, under ideal circumstances, are removed by naturally occurring antioxidants within the skin’s cells. In aging skin cells, antioxidants are in short supply. The free radicals generated are left unchecked and cause damage to cell membranes, proteins, and DNA. They eventually break down a protein substance in connective tissue (collagen) and release chemicals that cause inflammation of the skin. It is a combination of both the cellular and molecular events that leads to skin aging and the formation of wrinkles.”
  • Sam Shefer, Executive Vice President, Salvona Technologies
  • Extracellular Matrix (ECM)
  • DNP™ helps reduce the damaging effects on skin from a family of enzymes.
  • Enzymes activated by aging, stress, and smoking degrade extracellular matrix (ECM).
  • “Peptides stimulate key cellular processes and control cellular wall defense. They stimulate collagen and can regulate fibroblasts – the cells that are the foundation of tissue building. Peptides also protect cells from sugar deposition (glycation) and inhibit enz attacks on tissue which further hastens aging if such attacks occur. Signal peptides work to inhibit neurotransmission, melanin production and UV damage.”
  • Robin Carmichael, Marketing and Business Development, Helix BioMedix