Shopping Cart:

0 item(s)

  • Nevaline™ & Science
  • There is significant clinical evidence to support the topical efficacy of Nevaline™. DNP™ is a proprietary peptide and the active ingredient in the topical skincare product Nevaline™.
  • The following studies were conducted by independent, third-party research laboratories in the United States. The significant topical efficacy shown by these studies is supported by DNA micro-array and PCR array analyses which show that DNP™ regulates hundreds of genes relating to skin repair.
  • 0
  • Anti-Inflammation
  • In an in-vitro anti-inflammation model using human skin cell, DNP™ helped reduce nitric oxide produced during periods of skin inflammation by 76%.
  • "When synthesized at high concentrations, nitric oxide has been shown to play a decisive role in inflammatory and autoimmune tissue injury due to its cytotoxic and immunoregulatory properties. Thus, the magnitude and kinetics of nitric oxide synthesis by a mammalian cell determine whether its actions are regulatory or cytotoxic" (J Invest Dermatol. 1998 Jan: 110 (1):1-7)
Learn More
  • Endogenous nitric oxide (NO) has been compared to a double-edged sword, with many essential physiologic functions at low concentrations and toxic effects at higher concentrations. NO acts as a molecular messenger that mediates cell-to-cell communication throughout the body. This gaseous free radical also plays a role in neurotransmission, smooth muscle relaxation, and immune response, as well as other vital systems. In the skin, NO orchestrates normal regulatory processes, such as maintaining barrier function and determining blood flow rate in the microvasculature. NO also directs the skin’s response to external stimuli such as heat, ultraviolet (UV) light, infection, and wound healing. However, these external insults can lead to over-expression of NO, which can have damaging effects for skin. Inflammation, neurodegeneration, and hyperpigmentation are all associated with elevated levels of NO. For instance, the NO released following UV irradiation plays a significant role in initiating melanogenesis, erythema, and immunosuppression. By reducing the over-expression of NO, DNP™ reduces many factors that can lead to older-appearing skin.

     

hide
  • 0
  • Anti-Oxidation
  • In an in-vitro study on the cellular peroxide levels in human skin cells, DNP™ helped reduce levels of endogenous peroxide by 60% and exogenous peroxide by more than 90%.
  • “Skin aging is a complex biological process related to a decline in physiological and biochemical performance. A decline in the mitochondrial energy production is a feature of aging at the cellular level. This is partially attributed to excessive production of reactive oxygen species such as peroxide and hydrogen peroxide in aged individuals.” (Exp Gerontol. 2007 Sep; 42(9);924-9. Epub 2007 Mar 30.)
Learn More
  • A scientific study shows that DNP™ is a specific, functional compound that reduces endogenous and exogenous peroxide, both of which cause skin vulnerability and the premature loss of skin function.
hide
  • 0
  • Anti-Photodamage
  • In a human clinical study the topical application of Nevaline™ helped reduce the levels of free radicals by 400%.
  • “Environmental insults such as ultraviolet (UV) rays from sun, cigarette smoke exposure and pollutants, and the natural process of aging contribute to the generation of free radicals and reactive oxygen species (ROS) that stimulate the inflammatory process in the skin… UV causes depletion of cellular antioxidants and antioxidant enzymes (SOD, catalase), initiates DNA damage. The net result of all these effects is inflammation and free radical generation both reactive oxygen and nitrogen species.” (International Journal of Cosmetic Science, Volume 27, Number 1, February 2005, pp. 17-34(18).)
Learn More
  • DNP™ is a potent “scavenger” of free radicals, stopping the cascade of damaging reactions initiated by exposure to ultraviolet rays and thus protecting the skin against photodamage. In one study on human subjects, DNP™ reduced the levels of free radicals by 400%.
hide
  • 0
  • Stimulated Hyaluronic Acid Expression
  • In an in-vitro study on adult human dermal fibroblast cells DNP™ enhanced Hyaluronic Acid production by 40%, which may lead to skin rejuvenation and firmer, brighter, and better-moisturized skin.
  • “Hyaluronan (Hyaluronic acid) is a major component of the extracellular matrix of skin. The large volume of water of hydration associate with hyaluronan may be a mechanism for maintain the normal hydration of skin. As such, decreasing levels of hyaluronan deposition might underlie the changes associated with the aging process.” (J Invest Dermatol. 1994 Mar; 102(3): 385-9.)Mar 30.)
Learn More
  • Hyaluronic acid is a component of connective tissue whose function is to cushion and lubricate. Hyaluronic acid is responsible for the water content of skin. Hyaluronic acid abnormalities occur in acrogeria (prematurely wrinkled skin) and premature aging syndromes. Ultraviolet irradiation and cigarette smoke are known to degrade hyaluronic acid and induce damage to the dermal connective tissue and the extracellular matrix, which in turn leads to the aged appearance of photodamaged skin.

    In laboratory tests, DNP™ has been shown to stimulate hyaluronic acid production by 40%. Such increased levels may lead to skin rejuvenation and firmer, brighter, and better-moisturized skin.

hide
  • 0
  • Inhibits release of degrading Enzymes
  • In an in-vitro study with collagenase DNP™ helped decrease 72% of this enzyme activity which degrade collagen and causes visible signs of aging.
  • “Long term exposure to ultraviolet irradiation from sunlight causes premature skin aging (photoaging), characterized in part by wrinkles, altered pigmentation, and loss of skin tone. Photoaged skin displays prominent alterations in the collagenous extracellular matrix of connective tissue… Multiple exposures to ultraviolet irradiation lead to sustained elevations of degrading enzymes that degrade skin collagen and may contribute to that degrade skin collagen and may contribute to photoaging.” (The New England Journal of Medicine, Vol. 337:1419-1429, Nov. 13, 1997 No. 20)
Learn More
  • The integrity of the skin extracellular matrix (ECM) is important to conserve a youthful skin appearance. The degradation of the ECM is brought about by the release of a family of enzymes, from resident connective tissue cells and invading inflammatory cells. The degrading enzymes are activated by aging, exposure to ultraviolet rays, stress, environmental pollution, and smoking. DNP™ has a dose-dependant inhibitory effect on the degrading enzymes, but is not itself the inhibitor. Instead, it is a signaling molecule that triggers the expression of the appropriate inhibitors of the degrading enzymes to mitigate the degradation of the ECM brought about by the aging process.

    Connective tissues are maintained in dynamic equilibrium by the opposing effects of cellular synthesis and extracellular degradation. As a whole, this has a regulatory role in matrix and growth factor bioavailability. Degradation of the matrix is brought about by the release of neural proteinases from resident connective tissue cells and invading inflammatory cells.

    The degrading enzymes are required for homeostatic maintenance of the ECM but also have the capacity to degrade the ECM. Over-activation of the degrading enzymes have been linked to the pathogenesis of diseases characterized by the breakdown of connective tissue or the ECM. Over-expression of the degrading enzymes causes a diverse array of pathologies; ailments include skin aging, skin tone discoloration, inflammation, wound healing, body odor, oral cavity odor, resacea, acne, and hair growth modulation.

hide
  • Regulates ECM genes
  • In an ex vivo study in the formation and regulation of the extracellular matrix and adhesion molecules in human face lift surgical waste skin DNP™ helped to repair and maintain the extracellular matrix (ECM) of the facial skin.
  • The extracellular matrix (ECM) is a complex network of collagens, proteins, and enzymes that provides the microenvironment for skin cells and serves as a tissue scaffold, guiding cell migration during embryonic development and wound repair. Beyond that, it also functions as the repository and modulator of growth factors and cytokines, and therefore is responsible for transmitting environmental signals to the cells. The integrity of the ECM is important to conserve a youthful skin appearance.
Learn More
  • In laboratory studies conducted using human facial skin samples; topical application of DNP was shown to regulate six separate genes relating to the ECM. It increased the expression of three genes, generating proteins and collagens that strengthen both the upper and lower layers of the ECM. Further, it decreased the expression of three genes implicated in inflammation, carcinogenesis, and other deleterious skin process. Overall, DNI demonstrated a beneficial bioactivity profile consistent with dermal regeneration potential and a decrease of signaling pathways implicated in pathogenic effects on the skin.

     

hide